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Saccharin is the oldest and today the most famous artificial sweetener. It was discovered by Constantin Fahlberg in 1878 and soon after the discovery begins commercial use of saccharin. During the World War I, in a period of a shortage of sugar, enters in wide use. Saccharin is even 300-500 times sweeter than sugar and has almost no energy value and it is very popular as a dietary preparation. It is used in drinks, candy, medicines and toothpaste. Although very sweet, leaves a bitter taste in the mouth. Scientific studies conducted in rats showed that large doses of saccharin increase the risk of cancer. This discovery led to his ban. Saccharin is no longer forbidden, but should be clearly highlighted on the label of each product. The conventional wisdom is that saccharin is not an initiator but acts as a promoter of carcinogenesis (process of tumor formation) in the bladder. Today, its daily dose is limited to 50 milligrams. An interesting fact is that saccharin passes through the body unchanged, is not metabolized in the body.

Research conducted by Dr. Eran Elinav showed that the mice that received water sweetened with saccharin developed glucose intolerance. It proves that saccharin does unhealthy microbiome of mice, and similar results are obtained with the use of other artificial sweeteners. After these results, a research was conducted on a group of seven participants who had never consumed artificial sweeteners. For seven days they were given the maximum allowed daily dose of artificial sweeteners and four patients developed glucose intolerance.

In 1973 fifty year old female patient came to the hospital in Cleveland due to review the adrenal glands. She was suffering from obesity, hypertension, diabetes and excessive hairiness. It was noticed the occurrence of urticaria on the hands, face and back after the evening meal. Urticaria appeared for last three months. Doctors have linked the appearance of urticaria to saccharin intake through drinks that the patient regularly consumed, which contained 122 mg of saccharin per bottle. After the searches carried out, the patient cut out saccharin from her diet and problems with urticaria disappeared.

S. Fukushima and S. M. Cohen conducted a study on the connection between saccharin and bladder cancer in rats. Six week old rats are over 18 weeks treated with saccharin, and the control group of rats received the same diet, but without saccharin. The results showed that rats who received saccharin are not showing signs of toxicity, but it was noted that they are developing slower than the rats in the control group. This experiment confirmed the fact that saccharin is associated with the promoters of bladder cancer. Similar results were received by Samuel M. Cohen, Masayuki Aral, Jerome B. Jacobs and Gilbert H. Friedell after a study conducted in rats.


  1. “Promoting Effect of Saccharin and DL-Tryptophan in Urinary Bladder Carcinogenesis“,
    Samuel M. Cohen, Masayuki Aral, Jerome B. Jacobs i Gilbert H. Friedell,
  2. “Saccharin-induced Hyperplasia of the Rat Urinary Bladder“,
    Shoji Fukushima, Samuel M. Cohen,
  3. “Are Artificial Sweeteners Really That Bad for You?“
    Claire Suddath,
  4. “A case of episodic urticaria due to saccharin ingestion“,
    Ronald Miller, M.D., Lawrence W. White, M.D., and Howard J. Schwartz, M.D.
  5. “Saccharin“,
    Sanford A. Miller, PhD Victor P. Frattali, PhD
  6. “Bad news for artificial sweeteners“,