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Sucralose is an artificial sweetener and it is even 500-600 times sweeter than sucrose. It derives from sucrose in the process of chlorination and it is safer than aspartame and saccharin. The scientific researches underline the negative effects of sucralose on the thyroid, liver, kidneys and lymph nodes. The consumption of sucralose in large quantities disturbs the intestinal flora and promotes weight gain and causes migraines. Scientists emphasize the need to carry out further research in order to safely confirm the harmfulness of sucralose. In the declarations, sucralose can be recognized under the number E955, and is mostly used in chewing gum and products for baking. In 1991 was approved in Canada, in 1998 in the United States of America, but only in 2004 in the European Union. US Food and Drug Administration considers sucralose completely healthy sweetener.

In 2006 doctors Marcelo E. Bigal and Abouch V. Krymchantowski conducted a study in the case of a patient who has suffered from migraines. This study attempted to prove the connection between sucralose and the appearance of migraine. Although the article states that sucralose, unlike aspartame, is considered not to trigger the occurrence of migraine, this case proves that sucralose can be considered as the cause of migraine. Migraine occurs after consuming sucralose, during the period of not consuming sucralose it is stationary. Repeatedly taking sucralose affects the recurrence of migraines.