Scientific papers

[Warburg 1956] Warburg O. On the Origin of Cancer Cells. Science, New Series, Vol. 123, No. 3191. (Feb. 24, 1956), pp. 309-314.
click here

Warburg Effect
click here or click here

[Aras 2008] Aras B1, Kalfazade N, Tucu V, Kemahli E, Ozbay B, Polat H, Tai AI. Can lemon juice be an alternative to potassium citrate in the treatment of urinary calcium stones in patients with hypocitraturia? A prospective randomized study. Urol Res. 2008 Dec;36(6):313-7. doi: 10.1007/s00240-008-0152-6.
click here

[Zuckerman 2009] Zuckerman JM1, Assimos DG. Hypocitraturia: pathophysiology and medical management. Rev Urol. 2009 Summer;11(3):134-44.
click here

[Oussama 2005] Oussama A1, Touhami M, Mbarki M. In vitro and in vivo study of effect of lemon juice on urinary lithogenesis. Arch Esp Urol. 2005 Dec;58(10):1087-92.
click here

[Vander Heiden 2009] Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009; DOI:10.1126/science.1160809.
click here or click here

[Tracy 2009], Tracy CR, Pearle MS. Update on the medical management of stone disease. Current Opinion in Urology. 2009 March. Volume 19, Issue 2, p 200–204.
click here

[Vezyroglou 2016] Vezyroglou K, Cross JH. Targeted Treatment in Childhood Epilepsy Syndromes. Options Neurol 2016 May; 18: 29. DOI:10.1007/s11940-016-0407-4
click here

[Neal 2009] Neal EG, Chaffe H, Schwartz RH, Lawson MS, Edwards N, Fitzsimmons G, Whitney A, Cross JH. A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy. Epilepsia, Volume 50, Issue 5, 2009 May; DOI: 10.1111/j.1528-1167.2008.01870.x
click here

[Caldwell 2014] Caldwell B, Esselstyn JR., Gendy G, Doyle J, Golubic M, Roizen MF. A way to reverse CAD? Journal of Family Practice, 2014 Jul; p. 356+
click here

[Ruffin 2014] Ruffin VA, Salameh AI, Boron WF, Parker MD. Intracellular pH regulation by acid-base transporters in mammalian neurons. Front Physiol. 2014; 5: 43.; doi: 10.3389/fphys.2014.00043
click here

[Ishi 1982] Ishi DN. Effect of the suspected tumor promoters saccharin, cyclamate, and phenol on nerve growth factor binding and response in cultured embryonic chick ganglia. CANCER RESEARCH 42, 429-432, 1982 February
click here

[Ahmed 1992] Ahmed FE, Thomas DB. Assessment of the Carcinogenicity of the Nonnutritive Sweetener Cyclamate. Critical Reviews in Toxicology, Volume 22, Issue 2, 1992.
click here

[Takayama 2000] Takayama S, Renwick AG, Johansson SL, Thorgeirsson UP, Tsutsumi M, Dalgard DW, Sieber SM. Long-Term Toxicity and Carcinogenicity Study of Cyclamate in Nonhuman Primates. Toxicol Sci 53 (1): 33-39. 2000 January
click here

[Larsson 2012] Larsson SC, Wolk A. Red and processed meat consumption and risk of pancreatic cancer: meta-analysis of prospective studies. British Journal of Cancer, 2012 January; 106, 603–607. doi:10.1038/bjc.2011.585
click here

[Nöthlings 2005] Nöthlings U, Wilkens LR, Murphy SP, Hankin JH, Henderson BE, Kolonel LN. Meat and Fat Intake as Risk Factors for Pancreatic Cancer: The Multiethnic Cohort Study. Journal of the National Cancer Institute, Vol. 97, No. 19, 2005 October
click here

[Risch 2003] Risch HA. Etiology of Pancreatic Cancer, With a Hypothesis Concerning the Role of N-Nitroso Compounds and Excess Gastric Acidity. JNCI J Natl Cancer Inst 2003 July; 95 (13): 948-960.
click here

[Kijlstra 2008] Kijlstra A, Jongert E. Control of the risk of human toxoplasmosis transmitted by meat. International Journal for Parasitology, Volume 38, Issue 12, 2008 October; Pages 1359–1370
click here

[Ni 2016] Ni R, Gillberg PG, Bogdanovic N, Viitanen M, Myllykangas L, Nennesmo I, Langström B, Nordberg A. Amyloid tracers binding sites in autosomal dominant and sporadic Alzheimer’s disease. Alzheimer’s & Dementia – (2016) 1-12.
click here

[Mortensen 2006] Mortensen A. Sweeteners permitted in the European Union: safety aspects. Scandinavian Journal of Food and Nutrition 2006; 50 (3): 104-116; DOI: 10.1080/17482970600982719.
click here

[Drasar 1972] Drasar BS, Renwick AG, Williams RT. The Role of the Gut Flora in the Metabolism of Cyclamate. Biochem. J. (1972) 129, 881-890.
click here

[Anderson 2002] Anderson KE, Sinha R, Kulldorff M, Gross M, Lang NP, Barber C, Harnack L, DiMagno E,  Bliss R, Kadlubar FF. Meat intake and cooking techniques: associations with pancreatic cancer. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis;Volumes 506–507, 2002 September, Pages 225–231.
click here

[Norell 1986] Norell SE, Ahlbom A, Erwald R, Jacobson G, Lindberg-Navier I, Olin R, Tőrnberg B, Wiechel KL. DIET AND PANCREATIC CANCER: A CASE-CONTROL STUDY. Am J Epidemiol (1986) 124 (6): 894-902.
click here

[Magarian 1992] Magarian GJ, Lucas LM, Kumar KL. Clinical Significance in Alcoholic Patients of Commonly Encountered Laboratory Test Results. West J Med 1992 Mar; 156:287-294.
click here

[Anton 1996] Anton RF, Moak DH, Latham P. Carbohydrate-Deficient Transferrin as an Indicator of Drinking Status During a Treatment Outcome Study. Alcoholism: Clinical and Experimental Research, Volume 20, Issue 5, 1996 August; Pages 841–846; DOI: 10.1111/j.1530-0277.1996.tb05261.x.
click here

[Zein 1970] Zein M, Discombe G. Serum gamma-glutamyl transpeptidase as a diagnostic aid. The Lancet, Volume 296, Issue 7676, 1970 October, Pages 748–750.
click here

[Payne 1966] Payne JP, Hill DW, King NW. Observations on the Distribution of Alcohol in Blood, Breath, and Urine. Bnt. med. J., 1966, 1, 196-202.
click here

[Bosron 1986] Bosron WF, Li TK. Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology, Volume 6, Issue 3, 1986 May/June, Pages 502–510; DOI: 10.1002/hep.1840060330.
click here

[Bosron 1988] Bosron WF, Lumeng L, Li TK. Genetic polymorphism of enzymes of alcohol metabolism and susceptibility to alcoholic liver disease. Molecular Aspects of Medicine, Volume 10, Issue 2, 1988, Pages 147–158.
click here

[Julkunen 1985] Julkunen RJK, Tannenbauma L, Baraona E, Lieber CS. First pass metabolism of ethanol: An important determinant of blood levels after alcohol consumption. Alcohol ,Volume 2, Issue 3, 1985 May–June, Pages 437–441.
click here

[Reddy 2003] Reddy ST, Wang CY, Sakhaee K, Brinkley L, Pak CYC. Effect of Low-Carbohydrate High-Protein Diets on Acid-Base Balance, Stone-Forming Propensity, and Calcium Metabolism. Obstetrical & Gynecological Survey: 2003 February – Volume 58 – Issue 2 – pp 113-114.
click here

[Rieger 1999] Rieger MA, Parlesak A, Pool-Zobel BL, Rechkemmer G, Bode C. A diet high in fat and meat but low in dietary fibre increases the genotoxic potential of `faecal water’. Carcinogenesis (1999) 20 (12): 2311-2316; DOI: https://doi.org/10.1093/carcin/20.12.2311.
click here

[Minich 2007] Minich DM, Bland JS. Acid-alkaline balance: role in chronic disease and detoxification. ALTERNATIVE THERAPIES, 2007 jul/aug, VOL. 13, NO. 4.
click here

[Tracy 2009] Tracy Cr, Pearle MS. Update on the medical management of stone disease. Current opinion in urology 19(2):200-4, 2009 April; DOI: 10.1097/MOU.0b013e328323a81d.
click here

[Ramachandran 2001] Ramachandran V, Perez A, Chen J, Senthil D, Schenker S, Henderson GI. In Utero Ethanol Exposure Causes Mitochondrial Dysfunction, Which Can Result in Apoptotic Cell Death in Fetal Brain: A Potential Role for 4-Hydroxynonenal. Alcoholism: Clinical and Experimental Research, Volume 25, Issue 6, pages 862–871, 2001 June; DOI: 10.1111/j.1530-0277.2001.tb02292.x
click here

[Miksys 2003] Miksys S, Lerman C, Shields PG, Mash DC, Tyndale RF. Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain. Neuropharmacology, Volume 45, Issue 1, 2003 July, Pages 122–132.
click here

[Wang 1996] Wang H, Cao G, Prior RL. Total Antioxidant Capacity of Fruits. J. Agric. Food Chem. 1996, 44, 701−705.
click here

[Liao 2015] Liao S, von der Weid PY. Lymphatic System: An Active Pathway for Immune Protection. Semin Cell Dev Biol. 2015 February ; 38: 83–89. doi:10.1016/j.semcdb.2014.11.012.
click here

[Finberg 2006] Finberg RW, Kurt-Jones EA. An Unexpected Connection: Lymph Node Lymphangiogenesis and Dendritic Cell Migration. Immunity 24, 2006 February; DOI 10.1016/j.immuni.2006.01.011.
click here

[Wiig 2010] Wiig H, Keskin D, Kalluri R. Interaction between the extracellular matrix and lymphatics – consequences for lymphangiogenesis and lymphatic function. Matrix Biol. 2010 October ; 29(8): 645–656. doi:10.1016/j.matbio.2010.08.001.
click here

[Lavie 2015] Lavie CJ, Arena R, Swift DL, Johannsen NM, Sui X, Lee DC, Earnest CP, Church TS, O’Keefe JH, Milani RV, Blair SN. Exercise and the Cardiovascular System, Clinical Science and Cardiovascular Outcomes. Circ Res. 2015 July 3; 117(2): 207–219; doi:10.1161/CIRCRESAHA.117.305205.
click here

[Pack 2014] Pack QR, Rodriguez-Escudero JP, Thomas RJ, Ades PA, West CP, Somers VK, Lopez-Jimenez F. The Prognostic Importance of Weight Loss in Coronary Artery Disease: A Systematic Review and Meta-Analysis. Mayo Clin Proc. 2014 October ; 89(10): 1368–1377. doi:10.1016/j.mayocp.2014.04.033.
click here

[O’Keefe 2012] O’Keefe JH, Patil HR, Lavie CJ, Magalski A, Vogel RA, McCullough PA. Potential Adverse Cardiovascular Effects From Excessive Endurance Exercise. Mayo Clin Proc. 2012 June;87(6):587-595.
click here

[Garcia 2014] Garcia DO, Thomson CA. Physical Activity and Cancer Survivorship. Nutr Clin Pract. 2014 December ; 29(6): 768–779. doi:10.1177/0884533614551969.
click here

[Ceni 2014] Ceni E, Mello T, Galli A. Pathogenesis of alcoholic liver disease: Role of oxidative metabolism. World J Gastroenterol 2014 December 21; 20(47): 17756-17772.
click here

[Williams 2014] Williams JA, Manley S, Ding WX. New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases. World J Gastroenterol 2014 September 28; 20(36): 12908-12933.
click here

[Basra 2011] Basra S, Anand BS. Definition, epidemiology and magnitude of alcoholic hepatitis. World J Hepatol. 2011 May 27; 3(5): 108–113.
click here

[Knockaert 2011] Knockaert L, Fromenty B, Robin MA. Mechanisms of mitochondrial targeting of cytochromeP450 2E1: physiopathological role in liver injury andobesity. FEBS Journal 278 (2011) 4252–4260 Journal compilation; doi:10.1111/j.1742-4658.2011.08357.x.
click here

[Bigal 2006] Bigal ME, Krymchantowski AV. Migraine Triggered by Sucralose—A Case Report. HEADACHE, Volume 46, Issue 3, 2006 March, Pages 515–517;  DOI: 10.1111/j.1526-4610.2006.00386_1.x.
click here

[Binns 2003] Binns NM. Sucralose – all sweetness and light. British Nutrition Foundation Nutrition Bulletin, 28, 53–58, 2003.
click here

[Grotz 2004] Grotz VL, Henry RR, Mcgill JB, Pi-Sunyer X. Lack of effect of sucralose on glucose homeostasis in subjects with type 2 diabetes (T2DM). Journal of the American Dietetic Association 103(12):1607-12, 2004 January; DOI: 10.1016/j.jada.2003.09.021.
click here

[Whitehouse 2008] Whitehouse CR, Boullata J, McCauley LA. The Potential Toxicity of Artificial Sweeteners. Aaohn Journal, 2008, Volume: 56 issue: 6, page(s): 251-261.
click here

[Kille 2000] Kille J, Ford WCL, McAnulty P, Willoughby CR. Sucralose: Lack of effects on sperm glycolysis and reproduction in the rat. Food and Chemical Toxicology 38 Suppl 2:S19-29, 2000 February; DOI: 10.1016/S0278-6915(00)00025-9
click here

[Miller 1974] Miller R, White LW, Schwartz HJ. A case of episodic urticaria due to saccharin ingestion. Journal of Allergy and Clinical Immunology. Volume 53, Issue 4, 1974 April, Pages 240–242.
click here

[Fukushima 1980] Fukushima S, Cohen SM. Saccharin-induced Hyperplasia of the Rat Urinary Bladder. CANCER RESEARCH 40, 734-736, 1980 March.
click here

[Cohen 1979] Cohen SM, Aral M, Jacobs JB, Friedell GH. Promoting Effect of Saccharin and DL-Tryptophan in Urinary Bladder Carcinogenesis. CANCER RESEARCH39, 1207-1217, 1979 April.
click here

[Maher 1987] Maher TJ, Wurtman RJ. Possible Neurologic Effects of Aspartame, a Widely Used Food Additive. Environmental Health Perspectives, Vol. 75, pp. 53-57, 1987.
click here

[Soffritti 2007] Soffritti M, Belpoggi F, Tibaldi E, Esposti DD, Lauriola M. Life-Span Exposure to Low Doses of Aspartame Beginning during Prenatal Life Increases Cancer Effects in Rats. Environmental Health Perspectives, volume 115, number 9, 2007 September.
click here

[Anton 2010] Antona SD, Martin CK, Han H, Coulon S, Cefalu WT, Geiselman P, Williamson DA. Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Appetite, volume 55, Issue 1, 2010 August, Pages 37–43.
click here

[Soffritti 2006] Soffritti M, Belpoggi F, Esposti DD, Lambertini L, Tibaldi E, Rigano A. First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats. Environmental Health Perspectives, Vol. 114, No. 3 (Mar., 2006), pp. 379-385.
click here

[Roberts 2000] Roberts A, Renwick AG, Sims J, Snodin DJ. Sucralose metabolism and pharmacokinetics in man. Food and Chemical Toxicology, Volume 38, Supplement 2, 2000 July, Pages 31–41.
click here

[Abou-Donia 2008] Abou-Donia MB, El-Masry EM, Abdel-Rahman AA, McLendon RE, Schiffman SS. Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats. Journal of Toxicology and Environmental Health, Volume 71, 2008 – Issue 21, Pages 1415-1429.
click here

[Finn 2000] Finn JP, Lord GH. Neurotoxicity studies on sucralose and its hydrolysis products with special reference to histopathologic and ultrastructural changes. Food and Chemical Toxicology, Volume 38, Supplement 2, 2000 July, Pages 7–17.
click here

DEPARTMENT OF HEALTH AND HUMAN SERVICES, Food and Drug Administration, [Docket No. 76F-0392] Cyclamate (Cyclamlc Acid, Calcium Cyclamate, and Sodium Cyclamate), Commissioner’s Decision. Federal Register, Vol. 45, No. 181,  Tuesday, 1980 September 16.
click here

[Miller 1989] Miller SA, Fratta VP. Saccharin. Diabetes care, vol. 12, no. 1, suppl. 1, 1989 January.
click here

[Chakraborty 2010] Chakraborty S, Zawieja S, Wang W, Zawieja DC, Muthuchamy M. Lymphatic system acts as a vital link between metabolic syndrome and inflammation. Ann N Y Acad Sci. 2010 October ; 1207(Suppl 1): E94–102. doi:10.1111/j.1749-6632.2010.05752.x.
click here

[Knoops 2004] Knoops KTB, de Groot L, Kromhout D, Perrin AE, Moreiras-Varela O, Menotti A, van Staveren WA. Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project. 2004 American Medical Association; (Reprinted) JAMA, September 22/29, 2004—Vol 292, No. 12
Click here

[Mozaffarian 2011] Mozaffarian D, Hao T, Rimm EB, Willett WC, Hu FB. Changes in Diet and Lifestyle and Long-Term Weight Gain in Women and Men. N Engl J Med 2011; 364:2392-2404June 23, 2011DOI: 10.1056/NEJMoa1014296
Click here

[Bazzano 2008], Bazzano LA, Li TY, Joshipura KJ, Hu FB. Intake of Fruit, Vegetables, and Fruit Juices and Risk of Diabetes in Women. Diabetes Care 2008 Jul; 31(7): 1311-1317
Click here

[Elmer 2006], Elmer PJ, Obarzanek E, Vollmer WM, Simons-Morton D, Stevens VJ, Young DR, Lin PH, Champagne C, Harsha DW, Svetkey LP, Ard J, Brantley PJ, Proschan MA, Erlinger TP, Appel LJ. Effects of Comprehensive Lifestyle Modification on Diet, Weight, Physical Fitness, and Blood Pressure Control: 18-Month Results of a Randomized Trial. ACP J Club. 2006 Sep-Oct;145:42. doi:10.7326/ACPJC-2006-145-2-042
Click here

[Klarić 2016] Klarić I, Domačinović M, Pavić M, Miškulin I, Miškulin M, Steiner Z. The use of propolis and bee pollen in chickens feeding – a natural way to protect the Health of consumers. Hrana u zdravlju i bolesti, znanstveno-stručni časopis za nutricionizam i dijetetiku (2016) 5 (2) 37-43.
Click here

[Anand 2008] Anand P, Kunnumakara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB. Expert Review: Cancer is a Preventable Disease that Requires Major Lifestyle Changes. Pharmaceutical Research, Vol. 25, No. 9, September 2008 (# 2008); DOI: 10.1007/s11095-008-9661-9
Click here

[Mozaffarian 2011] Mozaffarian D, Hao T, Rimm EB, Willett WC, Hu FB. Changes in Diet and Lifestyle and Long-Term Weight Gain in Women and Men. N Engl J Med 2011; 364:2392-2404June 23, 2011DOI: 10.1056/NEJMoa1014296
Click here

[Pollard 2002] Pollard J, Kirk SFL, Cade JE. Factors affecting food choice in relation to fruit and vegetable intake: a review. Nutrition Research Reviews (2002), 15, 373–387 DOI: 10.1079/NRR200244
Click here

[Kellen 2008] Kellen E, Vansant G, Christiaens MR, Neven P, Limbergen E. Lifestyle changes and breast cancer prognosis: a review. Breast Cancer Research and Treatment, Springer Verlag, 2008, 114 (1), pp.13-22. <10.1007/s10549-008-9990-8>. <hal-00478334>
Click here

[Ammerman 2002] Ammerman AS, Lindquist CH, Lohr KN, Hersey J. The Efficacy of Behavioral Interventions to Modify Dietary Fat and Fruit and Vegetable Intake: A Review of the Evidence. Preventive Medicine, Volume 35, Issue 1, July 2002, Pages 25-41.
Click here

[Thompson 1999] Thompson RL, Margetts BM, Speller VM, McVey D. The Health Education Authority’s health and lifestyle survey 1993: who are the low fruit and vegetable consumers? Journal of Epidemiology & Community Health 1999;53:294-299.Click here

[Maynard 2002] Maynard M, Gunnell D, Emmett P, Frankel S, Smith GD. Fruit, vegetables, and antioxidants in childhood and risk of adult cancer: the Boyd Orr cohort. J Epidemiol Community Health 2003;57:218–225
Click here

[Cao 1998] Cao G, Booth SL, Sadowski JA, Prior RL. Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables. The American Journal of Clinical Nutrition 1998;68:1081–7
Click here

[Esposito 2003] Esposito K, Pontillo A, Di Palo C, Giugliano G, Masella M, Marfella R, Giugliano D. Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women. A Randomized Trial. JAMA. 2003;289(14):1799-1804. doi:10.1001/jama.289.14.1799
Click here

[Esposito 2006] Esposito K, Ciotola M, Giugliano F, De Sio M, Giugliano G, D’armiento M, Giugliano D. Mediterranean diet improves erectile function in subjects with the metabolic syndrome. International Journal of Impotence Research (2006) 18, 405–410. doi:10.1038/sj.ijir.3901447; published online 5 January 2006
Click here

[Bendinelli 2011] Bendinelli B, Masala G, Saieva C, Salvini S, Calonico S, Sacerdote C, Agnoli C, Grioni S, Frasca G, Mattiello A, Chiodini P, Tumino R, Vineis P, Palli D, Panico S. Fruit, vegetables, and olive oil and risk of coronary heart disease in Italian women: the EPICOR Study. Am J Clin Nutr 2011;93:275–83.
Click here

[Cooper 2012] Cooper AJ, Sharp SJ, Lentjes MAH, Luben RN, Khaw KT, Wareham NJ, Forouhi NG. A prospective study of the association between quantity and variety of fruit and vegetable intake and incident type 2 diabetes. Diabetes Care. 2012 Jun; 35(6): 1293–1300; Published online 2012 Apr 3. doi:  10.2337/dc11-2388
Click here

[Darmon 2008] Darmon N, Drewnowski A. Does social class predict diet quality? Am J Clin Nutr, May 2008; vol. 87 no. 5 1107-1117
Click here

[Beilin 1999] Beilin LJ, Puddey IB, Burke V. Lifestyle and Hypertension. Am J Hypertens 1999;12:934–945
Click here

[Schulze 2006] Schulze MB, Fung TT, Manson JE, Willett WC, Hu FB. Dietary Patterns and Changes in Body Weight in Women. 2006 North American Association for the Study of Obesity (NAASO); DOI: 10.1038/oby.2006.164
Click here